Listing a study does not mean it has been evaluated by the U.S. Federal Government. This has only been studied in cell lines where memantine does bind to D2 receptors; however, its action is very short-lived, making it difficult to measure. Some evidence suggests that memantine may have potential as a complementary medication to help treat addiction and other substance use disorders (meaning that it is used together with other, more “conventional” drugs – and not used just on its own). Result. The Effect of Intraperitoneal Memantine Injection on Anxiety-Like Behavior in Stressed Rats. Another study reported a slight improvement or no benefit of memantine in DLB . Your email address will not be published. None of the patients were allowed to take benzodiazepines during the course of the study. Week 4/Maintenance Dose: 20 mg orally/day (Administer 10 mg twice a day.) This suggests that it may be an option to treat alcoholism, although additional studies in human patients will be needed to know for sure how much clinical potential it might have in such cases . Week 2: 10 mg orally/day (Administer 5 mg twice a day.) Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS. Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. Similarly mean HAD-A dropped from baseline value of 13.2 to 8.4. Only a medical professional is properly qualified to determine the specific dosage that will be ideal for any individual case – and it is important to always discuss treatment plans with your doctor, and to follow their directions as carefully and accurately as you can to ensure the best treatment. Jonathan Ritter, PharmD, PhD (Pharmacology), Flea Bites on Humans & Pets: Symptoms & Treatment, Extended-release (24 hours) 7 mg, 14 mg, 21 mg, and 28 mg capsules. Memantine is a drug approved for the treatment of moderate-to-severe Alzheimer’s disease. According to one study, sixty patients who took memantine daily for their migraines had an average of 3.4 fewer migraines per month, whereas the placebo group only had 1 less per month . One small study concluded that âmemantine may be an effective augmentation therapy in patients with treatment-resistant anxiety.â 14 Memantine will not cure Alzheimer's disease, and it will not stop the disease from getting worse. Main eligibility criteria included:(i)male and female outpatients aged 18–65 with a DSM-IV diagnosis of either generalized or social anxiety disorder based on MINI diagnostic interview;(ii)rating of at least “moderately ill” (score of 4) on the Clinical Global Impressions of Severity (CGI-S) scale and score of at least 10 on HAM-A and 5 on HADS anxiety subscale;(iii)failure to respond adequately to trial of conventional anxiolytic;(iv)adequate treatment duration was considered 4 weeks at therapeutic dose;(v)adequate response is defined as an improvement of ≥50% in symptoms of anxiety on current anxiolytic therapy, as measured subjectively by patients or objectively by physician;(vi)stable on current psychiatric medication for ≥6 weeks prior to study entry. Memantine’s main mechanism is through glutamate NMDA receptor inhibition in the brain. For example, a double-blind randomized controlled trial in 80 young adults with opioid dependence treated with buprenorphine and/or naloxone were also given either memantine or a placebo. 1) Slows the Progression of Moderate-to-Severe Alzheimerâs Disease, 5) May Decrease Symptoms of Generalized Anxiety Disorder (GAD), 6) May Decrease Symptoms of Obsessive-Compulsive Disorder (OCD), 7) May Reduce the Negative Symptoms of Schizophrenia, 2) May Help Treat Migraines and Headaches, 3) May Help with Short-Term Treatment of Substance Use Disorders, 4) May Protect Against Mild Traumatic Brain Injury, 5) May Delay Amyotrophic Lateral Sclerosis (ALS). Memantine quickly binds to and blocks NMDA receptors, which can counteract toxicity caused by too much excitation (excitotoxicity), and thereby prevents programmed cell death (apoptosis) . Memantine may be an effective augmentation therapy in patients with anxiety who remain symptomatic despite adequate treatment with conventional antidepressant anxiolytics. According to one case study, a 74-year-old man improperly diagnosed with Alzheimer’s and parkinsonism (tremor, slow movement, impaired speech) was started on memantine, and reportedly developed severe changes in awareness, visual hallucinations, agitation, and worsening parkinsonism. This was a ten-week, single-center, open-label study for which fifteen patients were enrolled after obtaining Institutional review board approval. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. These functions included improvement in emotional control, self-monitoring, planning, and organizational skills . 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